Cardiomyopathies - The special entity of myocarditis and inflammatory cardiomyopathy

Maron BJ, Towbin JA, Thiene G, Antzelevitch C, Corrado D, et al.Contemporary definitions and classification of the cardiomyopathies: an American Heart Association Scientific Statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; and Council on Epidemiology and Prevention. Circulation. 2006; 113: 1807–1816. Ref.: http://bit.ly/2LuKdbV

Elliott P, Andersson B, Arbustini E, Bilinska Z, Cecchi F, et al. Classification of the cardiomyopathies: a position statement from the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur Heart J. 2008; 29: 270–276. Ref.: http://bit.ly/2LuE1AC

Braunwald E. Cardiomyopathies: An Overview. Circ Res. 2017; 121: 711-721. Ref.: http://bit.ly/2ZXH8VJ

McKenna WJ, Maron BJ, Thiene G. Classification, Epidemiology, and Global Burden of Cardiomyopathies. Circ Res. 2017; 121: 722-730. Ref.: http://bit.ly/3210w65

Rose NR, Cihakova D. Cardiomyopathies. Autoimmunity. 2004; 37: 347-350.

Caforio AL, Pankuweit S, Arbustini E, Basso C, Gimeno-Blanes J, et al. Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur Heart J. 2013; 34: 2636-2648. Ref.: http://bit.ly/2xmI1uJ

Schultheiss HP, Kuehl U, Cooper LT. The Management of Myocarditis. Eur Heart J. 2011; 32: 2616–2665. Ref.: http://bit.ly/2XJir1G

Sagar S, Liu PP, Cooper LT. Myocarditis. Lancet. 2013; 379: 738–747. Ref.: http://bit.ly/2WTHXNx

Calabrese F, Thiene G. Myocarditis and inflammatory cardiomyopathy: microbiological and molecular biological aspects. Cardiovasc Res. 2003; 60: 11-25. Ref.: http://bit.ly/2XfjgQy

Pollack A, Kontorovich AR, Fuster V, Dec GW. Viral myocarditis--diagnosis, treatment options, and current controversies. Nat Rev Cardiol. 2015; 12: 670-680. Ref.: http://bit.ly/323VPZ5

Bracamonte-Baran W, Čiháková D. Cardiac Autoimmunity: Myocarditis. Adv Exp Med Biol. 2017; 1003: 187-221. Ref.: http://bit.ly/2RMeJ1U

Schultheiss HP, Fairweather D, Caforio ALP, Escher F, Hershberger RE, et al. Dilated cardiomyopathy. Nat Rev Dis Primers. 2019; 5: 32. Ref.: http://bit.ly/2XktA9O

Rapezzi C, Arbustini E, Caforio AL, Charron P, Gimeno-Blanes J, et al. Diagnostic work-up in cardiomyopathies: bridging the gap between clinical phenotypes and final diagnosis. A position statement from the ESC Working Group on Myocardial and Pericardial Diseases. Eur Heart J. 2013; 34: 1448-1458. Ref.: http://bit.ly/2Yol0nd

Agrawal N, Khunger A, Vachhani P, Colvin TA, Hattoum A, et al. Cardiac Toxicity Associated with Immune Checkpoint Inhibitors: Case Series and Review of the Literature. Case Rep Oncol. 2019 21; 12: 260-276. Ref.: http://bit.ly/2J0b8L6

Merlo M, Cannatà A, Gobbo M, Stolfo D, Elliott PM, et al. Evolving concepts in dilated cardiomyopathy. Eur J Heart Fail. 2018; 20: 228-239. Ref.: http://bit.ly/2JgyScQ

Weintraub RG, Semsarian C, Macdonald P. Dilated cardiomyopathy. Lancet. 2017; 390: 400-414. Ref.: http://bit.ly/2XlLZTN

Trachtenberg BH, Hare JM. Inflammatory Cardiomyopathic Syndromes. Circ Res. 2017; 121: 803-818. Ref.: http://bit.ly/2FLdsU9

Caforio AL, Marcolongo R, Basso C, Iliceto S. Clinical presentation and diagnosis of myocarditis. Heart. 2015; 101: 1332-1344. Ref.: http://bit.ly/2LvK8Vd

Liu PP, Schultheiss HP. Myocarditis. In: Braunwald ed, Heart Disease. 8 ed. Philadelphia: W B Saunders co; 2008; 1775-1792.

Heymans S, Eriksson U, Lehtonen J, Cooper LT Jr. The Quest for New Approaches in Myocarditis and Inflammatory Cardiomyopathy. J Am Coll Cardiol. 2016; 68: 2348-2364. Ref.: http://bit.ly/2J0QF8S

Escher F, Kasner M, Kühl U, Heymer J, Wilkenshoff U, et al. New echocardiographic findings correlate with intramyocardial inflammation in endomyocardial biopsies of patients with acute myocarditis and inflammatory cardiomyopathy. Mediators Inflamm. 2013; 2013: 875420. Ref.: http://bit.ly/2NpKyPR

Lurz P, Luecke C, Eitel I, Föhrenbach F, Frank C, et al. Comprehensive Cardiac Magnetic Resonance Imaging in Patients With Suspected Myocarditis: The MyoRacer-Trial. J Am Coll Cardiol. 2016; 19; 67: 1800-1811. Ref.: http://bit.ly/2ZYyvdA

Friedrich MG, Sechtem U, Schulz-Menger J, Holmvang G, Alakija P, et al. International Consensus Group on Cardiovascular Magnetic Resonance in Myocarditis, et al. Cardiovascular magnetic resonance in myocarditis: A JACC White Paper. J Am Coll Cardiol. 2009; 53: 1475–1487. Ref.: http://bit.ly/2Yot4Et

Thiene G, Bruneval P, Veinot J, Leone O. Diagnostic use of the endomyocardial biopsy: a consensus statement. Virchows Arch. 2013; 463: 1-5. Ref.: http://bit.ly/2J19LMg

Cooper LT, Baughman KL, Feldman AM, Frustaci A, Jessup M, et al. The role of endomyocardial biopsy in the management of cardiovascular disease. Eur Heart J. 2007; 28: 3076–3093. Ref.: http://bit.ly/2LupzsC

Leone O, Veinot JP, Angelini A, Baandrup UT, Basso C, et al. 2011 consensus statement on endomyocardial biopsy from the Association for European Cardiovascular Pathology and the Society for Cardiovascular Pathology. Cardiovasc Pathol. 2012; 21: 245-274. Ref.: http://bit.ly/2Lt4ej6

Basso C, Calabrese F, Angelini A, Carturan E, Thiene G. Classification and histological, immunohistochemical, and molecular diagnosis of inflammatory myocardial disease. Heart Fail Rev. 2013; 18: 673-681. Ref.: http://bit.ly/303njwl

Thiene G, Bruneval P, Veinot J, Leone O. Diagnostic use of the endomyocardial biopsy: a consensus statement. Virchows Arch. 2013; 463: 1-5. Ref.: http://bit.ly/2J19LMg

Ishibashi-Ueda H, Matsuyama TA, Ohta-Ogo K, Ikeda Y. Significance and Value of Endomyocardial Biopsy Based on Our Own Experience. Circ J. 2017; 24; 81: 417-426. Ref.: http://bit.ly/2Nlyzm5

Kühl U, Pauschinger M, Noutsias M, Seeberg B, Bock T, et al. High prevalence of viral genomes and multiple viral infections in the myocardium of adults with "idiopathic" left ventricular dysfunction. Circulation. 2005; 111: 887-893. Ref.: http://bit.ly/2Lvf9so

Holzmann M, Nicko A, Kühl U, Noutsias M, Poller W, et al. Complication rate of right ventricular endomyocardial biopsy via the femoral approach. Circulation 2008; 118: 1722–1728. Ref.: http://bit.ly/2RPyfL1

Escher F, Lassner D, Kühl U, Gross U, Westermann D, et al. Analysis of Endomyocardial Biopsies in suspected Myocarditis - Diagnostic Value on Left versus Right Ventricular Biopsy. Int J Cardiol. 2014; 177: 76-78. Ref.: http://bit.ly/2YoRptM

Aretz HT. Myocarditis: the Dallas criteria. Hum. Pathol. 1987; 18: 619–624. Ref.: http://bit.ly/2FJ6wHb

Towbin JA, Lowe AM, Colan SD, Sleeper LA, Orav EJ, et al. Incidence, causes, and outcomes of dilated cardiomyopathy in children. JAMA. 2006; 296: 1867-1876. Ref.: http://bit.ly/2FGB8ZF

Bowles NE, Ni J, Kearney DL, Pauschinger M, Schultheiss HP, et al. Detection of viruses in myocardial tissues by polymerase chain reaction. Evidence of adenovirus as a common cause of myocarditis in children and adults. J Am Coll Cardiol. 2003; 42: 466–472. Ref.: http://bit.ly/2KRjqHk

Pauschinger M, Phan MD, Doerner A, Kuehl U, Schwimmbeck PL, et al. Enteroviral RNA replication in the myocardium of patients with left ventricular dysfunction and clinically suspected myocarditis. Circulation. 1999; 99: 889–895. Ref.: http://bit.ly/325qjKj

Kühl U, Rohde M, Lassner D, Gross UM, Escher F, et al. miRNA as activity markers in Parvo B19 associated heart disease. Herz. 2012; 37: 637-643. Ref.: http://bit.ly/2XhbYM9

Kuchynka P, Palecek T, Masek M, Cerny V, Lambert L, et al. Current Diagnostic and Therapeutic Aspects of Eosinophilic Myocarditis. Biomed Res Int. 2016; 2016: 2829583. Ref.: http://bit.ly/322bpVq

Maleszewski JJ, Orellana VM, Hodge DO, Kuhl U, Schultheiss HP, et al. Long-term risk of recurrence, morbidity and mortality in giant cell myocarditis. Am J Cardiol. 2015; 115: 1733-1738. Ref.: http://bit.ly/2J0altr

Larsen BT, Maleszewski JJ, Edwards WD, Cooper LT Jr, Sobonya RE, et al. Atrial giant cell myocarditis: a distinctive clinicopathologic entity. Circulation. 2013; 127: 39-47. Ref.: http://bit.ly/2xpMBIw

Lassner D, Kühl U2, Siegismund CS3, Rohde M3, Elezkurtaj S, et al. Improved diagnosis of idiopathic giant cell myocarditis and cardiac sarcoidosis by myocardial gene expressing profil. Eur Heart J. 2014; 35: 2186-2195. Ref.: http://bit.ly/2KOmaoX

Grogan M, Redfield MM, Bailey KR, Reeder GS, Gersh BJ, et al. Long-term outcome of patients with biopsy-proved myocarditis: comparison with idiopathic dilated cardiomyopathy. J Am Coll Cardiol. 1995; 26: 80-84. Ref.: http://bit.ly/323vgDq

Schultheiss HP, Kühl U. Why is diagnosis of infectious myocarditis such a challenge? Expert Rev Anti Infect Ther. 2011; 9: 1093-1095. Ref.: http://bit.ly/2YuuXzC

Kühl U, Lassner D, von Schlippenbach J, Poller W, Schultheiss HP, et al. Interferon-Beta improves survival in enterovirus-associated cardiomyopathy. J Am Coll Cardiol. 2012; 60: 1295-1296. Ref.: http://bit.ly/31ZqlDy

Verdonschot J, Hazebroek M, Merken J, Debing Y, Dennert R, et al. Relevance of cardiac parvovirus B19 in myocarditis and dilated cardiomyopathy: review of the literature. Eur J Heart Fail. 2016; 18: 1430-1441. Ref.: http://bit.ly/322hDVi

Hjalmarsson C, Liljeqvist JÅ, Lindh M, Karason K, Bollano E, et al. Parvovirus B19 in Endomyocardial Biopsy of Patients With Idiopathic Dilated Cardiomyopathy: Foe or Bystander? J Card Fail. 2019; 25: 60-63. Ref.: http://bit.ly/2Nq3vBP

Verdonschot JAJ, Cooper LT, Heymans SRB. Parvovirus B19 in Dilated Cardiomyopathy: There Is More Than Meets the Eye. J Card Fail. 2019; 25: 64-66. Ref.: http://bit.ly/2YotqLb

Kühl U, Lassner D, Pauschinger M, Gross UM, Seeberg B, et al. Prevalence of erythrovirus genotypes in the myocardium of patients with dilated cardiomyopathy. J Med Virol. 2008; 80: 1243-1251. Ref.: http://bit.ly/2YnP7Lu

Schmidt-Lucke C, Spillmann F, Bock T, Kühl U, Van Linthout S, e al. Interferon beta modulates endothelial damage in patients with cardiac persistence of human parvovirus b19 infection. J Infect Dis. 2010; 201: 936-945. Ref.: http://bit.ly/2XjAaO6

Schmidt-Lucke C, Zobel T, Schrepfer S, Kuhl U, Wang D, et al. Impaired Endothelial Regeneration Through Human Parvovirus B19-Infected Circulating Angiogenic Cells in Patients With Cardiomyopathy. J Infect Dis. 2015; 212: 1070-1081. Ref.: http://bit.ly/2XdkBCK

Kuhl U, Lassner D, Dorner A, Rohde M, Escher F, et al. A distinct subgroup of cardiomyopathy patients characterized by transcriptionally active cardiotropic erythrovirus and altered cardiac gene expression. Basic Res Cardiol. 2013; 108: 372. Ref.: http://bit.ly/2XmaQXN

Escher F, Kühl U, Gross U, Westermann D, Poller W, et al. Aggravation of left ventricular dysfunction in patients with biopsy-proven cardiac human herpesvirus A and B infection. J Clin Virol. 2015; 63: 1-5. Ref.: http://bit.ly/2ZY0ZUL

Pellett PE, Ablashi DV, Ambros PF, Agut H, Caserta MT, et al. Chromosomally integrated human herpesvirus 6: questions and answers. Rev Med Virol. 2012; 22: 144-155. Ref.: http://bit.ly/2Nozkem

Kühl U1, Lassner D, Wallaschek N, Gross UM, Krueger GR, et al. Chromosomally integrated human herpesvirus 6 in heart failure: prevalence and treatment. Eur J Heart Fail. 2015; 17: 9-19. Ref.: http://bit.ly/2xoAyeM

Escher F, Kühl U, Lassner D et al. Presence of Perforin in Endomyocardial Biopsies of Patients with Inflammatory Cardiomyopathy Predicts Poor Outcome. Eur J Heart Fail. 2014; 16: 1066-1072. Ref.: http://bit.ly/2XJ6xVH

Baldeviano GC, Barin JG, Talor MV, Srinivasan S, Bedja D, et al. Interleukin-17A is dispensable for myocarditis but essential for the progression to dilated cardiomyopathy. Circ Res. 2010; 106: 1646-1655. Ref.: http://bit.ly/2JkDkqL

Wu L, Ong S, Talor MV, Barin JG, Baldeviano GC, et al. Cardiac fibroblasts mediate IL-17A-driven inflammatory dilated cardiomyopathy. J Exp Med. 2014; 211: 1449-1464. Ref.: http://bit.ly/2FHTWaY

Myers JM, Cooper LT, Kem DC, Stavrakis S, Kosanke SD, et al. Cardiac myosin-Th17 responses promote heart failure in human myocarditis. JCI Insight. 2016; 1. Ref.: http://bit.ly/325QYqi

Rahmati Z, Amirzargar AA, Saadati S, Rahmani F, Mahmoudi MJ, et al. Association of levels of interleukin 17 and T-helper 17 count with symptom severity and etiology of chronic heart failure: a case-control study. Croat Med J. 2018 31; 59: 139-148. Ref.: http://bit.ly/2XkFctq

Wu L, Diny NL, Ong S, Barin JG, Hou X, et al. Pathogenic IL-23 signaling is required to initiate GM-CSF-driven autoimmune myocarditis in mice. Eur J Immunol. 2016; 46: 582-592. Ref.: http://bit.ly/2Xkalxr

Suthahar N, Meijers WC, Silljé HHW, de Boer RA. From Inflammation to Fibrosis-Molecular and Cellular Mechanisms of Myocardial Tissue Remodelling and Perspectives on Differential Treatment Opportunities. Curr Heart Fail Rep. 2017; 14: 235-250. Ref.: http://bit.ly/2NpphFY

Westermann D, Lindner D, Kasner M, Zietsch C, Savvatis K, et al. Cardiac inflammation contributes to changes in the extracellular matrix in patients with heart failure and normal ejection fraction. Circ Heart Fail. 2011; 4: 44-52. Ref.: http://bit.ly/2Lz9y4F

Piek A, de Boer RA, Silljé HH. The fibrosis-cell death axis in heart failure. Heart Fail Rev. 2016; 21: 199-211. Ref.: http://bit.ly/2FN1gCu

Schultheiss HP, Escher F. The ESC Textbook of Cardiovascular Medicine, Third Edition, 2019. Chapter 32.21: Myocarditis - Treatment of myocarditis.

Hershberger RE, Hedges DJ, Morales A. Dilated cardiomyopathy: the complexity of a diverse genetic architecture. Nat Rev Cardiol. 2013; 10: 531-547. Ref.: http://bit.ly/2FJbDY2

Heymans S, Hirsch E, Anker SD, Aukrust P, Balligand JL, et al. Inflammation as a therapeutic target in heart failure? A scientific statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail. 2009; 11: 119-129. Ref.: http://bit.ly/2RQbarQ

Sotiriou E, Heiner S, Jansen T, Brandt M, Schmidt KH, et al. Therapeutic implications of a combined diagnostic workup including endomyocardial biopsy in an all-comer population of patients with heart failure: a retrospective analysis. ESC Heart Fail. 2018; 5: 630-641. Ref.: http://bit.ly/2XAjvVO

Kühl U, Pauschinger M, Schwimmbeck PL, Seeberg B, Lober C, et al. Interferon-beta treatment eliminates cardiotropic viruses and improves left ventricular function in patients with myocardial persistence of viral genomes and left ventricular dysfunction. Circulation. 2003; 107: 2793-2798. Ref.: http://bit.ly/2FIR3H6

Schultheiss HP, Piper C, Sowade O, Waagstein F, Kapp JF, et al. Betaferon in chronic viral cardiomyopathy (BICC) trial: Effects of interferon-β treatment in patients with chronic viral cardiomyopathy. Clin Res Cardiol. 2016; 105: 763-773. Ref.:

Poller W, Kaya Z, Muche M, Kasner M, Skurk C, et al. High incidence of cardiac dysfunction and response to antiviral treatment in patients with chronic hepatitis C virus infection. Clin Res Cardiol. 2017; 106: 551-556. Ref.: http://bit.ly/2XNmg6p

Zobel T, Bock CT, Kühl U, Rohde M, Lassner D, Schultheiss HP, Schmidt-Lucke C. Telbivudine Reduces Parvovirus B19-Induced Apoptosis in Circulating Angiogenic Cells. Viruses. 2019; 11. Ref.: http://bit.ly/300osEJ

Cooper LT. The heat is off: immunosuppression for myocarditis revisited. Eur Heart J. 2009; 30: 1936-1939. Ref.: http://bit.ly/2ZXB7Za

Frustaci A, Russo MA, Chimenti C. Randomized study on the efficacy of immunosuppressive therapy in patients with virus-negative inflammatory cardiomyopathy: the TIMIC study. Eur Heart J. 2009; 30: 1995-2002. Ref.: http://bit.ly/2KQSQy8

Frustaci A, Chimenti C, Calabrese F, Pieroni M, Thiene G, et al. Immunosuppressive therapy for active lymphocytic myocarditis: virological and immunologic profile of responders versus nonresponders. Circulation. 2003; 107: 857-863. Ref.: http://bit.ly/2XgJdzf

Escher F, Kühl U, Lassner D, Poller W, Westermann D, et al. Long-term outcome of patients with virus-negative chronic myocarditis or inflammatory cardiomyopathy after immunosuppressive therapy. Clin Res Cardiol. 2016; 105: 1011-1020. Ref.: http://bit.ly/2XDKHmG

McNamara DM, Holubkov R, Starling RC, Dec GW, Loh E, et al. Controlled trial of intravenous immune globulin in recent-onset dilated cardiomyopathy. Circulation. 2001; 103: 2254-2259. Ref.: http://bit.ly/2FIRJfC

Felix SB, Staudt A, Dörffel WV, Stangl V, Merkel K, et al. Hemodynamic effects of immunoadsorption and subsequent immunoglobulin substitution in dilated cardiomyopathy: three-month results from a randomized study. J Am Coll Cardiol. 2000; 35: 1590-1598. Ref.: http://bit.ly/321yIym

Fan Y, Weifeng W, Yuluan Y, Qing K, Yu P, et al. Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of coxsackievirus b3-induced viral myocarditis reduces myocardium inflammation. Virol J. 2011; 8: 17. Ref.: http://bit.ly/2YxyrkV

Adegbala O, Olagoke O, Akintoye E, Adejumo AC, Oluwole A, et al. Predictors, Burden, and the Impact of Arrhythmia on Patients Admitted for Acute Myocarditis. Am J Cardiol. 2019; 123: 139-144. Ref.: http://bit.ly/2ZWMsZB

Caforio ALP, Cheng C, Perazzolo Marra M, Tarantini G, Basso C, et al. How to improve therapy in myocarditis: role of cardiovascular magnetic resonance and of endomyocardial biopsy. Eur Heart J Suppl. 2019; 21(Suppl B): B19-B22. Ref.: http://bit.ly/2YxVDiA

Caforio AL, Mahon NJ, Mckenna WJ. Cardiac autoantibodies to myosin and other heart-specific autoantigens in myocarditis and dilated cardiomyopathy. Autoimmunity. 2001; 34: 199-204. Ref.: http://bit.ly/2XeOGBy

Kasner M, Aleksandrov A, Escher F, Al-Saadi N, Makowski M, et al. Multimodality imaging approach in the diagnosis of chronic myocarditis with preserved left ventricular ejection fraction (MCpEF): The role of 2D speckle-tracking echocardiography. Int J Cardiol. 2017; 243: 374-378. Ref.: http://bit.ly/2RLy6IE

Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JGF, et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2016; 37: 2129-2200. Ref.: http://bit.ly/2J1m4bd

Gorbea C, Makar KA, Pauschinger M, Pratt G, Bersola JL, et al. A role for Toll-like receptor 3 variants in host susceptibility to enteroviral myocarditis and dilated cardiomyopathy. J Biol Chem. 2010; 285: 23208-23223. Ref.: http://bit.ly/2XfsffM

Zimmermann O, Rodewald C, Radermacher M, Vetter M, Wiehe JM, et al. Interferon beta-1b therapy in chronic viral dilated cardiomyopathy--is there a role for specific therapy? J Card Fail. 2010; 16: 348-356. Ref.: http://bit.ly/2XD8pPH

Bachelier K, Biehl S, Schwarz V, Kindermann I, Kandolf R, et al. Parvovirus B19-induced vascular damage in the heart is associated with elevated circulating endothelial microparticles. PLoS One. 2017; 12: e0176311. Ref.: http://bit.ly/2XFMpnt

Kühl U, Rohde M, Lassner D, Gross UM, Escher F, et al. miRNA as activity markers in Parvo B19 associated heart disease. Herz. 2012; 37: 637-643. Ref.: http://bit.ly/2XhbYM9